Biocompatibility evaluation of a thermoplastic rubber for wireless telemetric intracranial pressure sensor coating


Jun Yang1, Andrea C. Charif4,5, Judit E. Puskas4,5, Hannah Phillips1, Kaitlyn J. Shanahan1, Jessica Garsed1, Aaron Fleischman2, Ken Goldman3, Matthew T. Luebbers4, Stephen M. Dombrowski1, Mark G. Luciano1

1 Department of Neurosurgery, Section of Pediatric and Congenital Neurological Surgery, CSF Physiology Laboratory, Neurological Institute, S60, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA

2 Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA

3 H-Cubed, Inc., Olmsted Falls, OH 44138, USA

4 Department of Chemical and Biomolecular Engineering, the University of Akron, USA

5 Department of Polymer Science, the University of Akron, USA


This study investigated the biocompatibility of the exptl. thermoplastic rubber Arbomatrix that will be used as the protective coating on a novel intracranial pressure (ICP) sensor silicon chip.  Arbomatrix was benchmarked against biocompatible com. silicone rubber shunt tubing in the brain via a rat model with 60-​day implant duration.  A bare silicon chip was also implanted.  The results showed similar cellular distribution in the brain-​implant boundary and surrounding tissues.  Quant. anal. of neuron and glia d. did not show significant difference between implants.  Through histol. and immunohistochem. evaluation we conclude that Arbomatrix is well tolerated by the brain.  Due to its exceptional barrier properties Arbomatrix has already been shown to be an excellent protective coating for new ICP monitoring chip.

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